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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD6
All Species:
12.42
Human Site:
S435
Identified Species:
22.78
UniProt:
O43541
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43541
NP_001136333.1
496
53497
S435
R
K
V
P
P
G
Y
S
I
K
V
F
D
F
E
Chimpanzee
Pan troglodytes
XP_523105
496
53474
S435
R
K
V
P
P
G
Y
S
I
K
V
F
D
F
E
Rhesus Macaque
Macaca mulatta
XP_001104638
454
49165
S393
R
K
V
P
P
G
Y
S
I
K
V
F
D
F
E
Dog
Lupus familis
XP_544737
499
53465
I438
K
V
P
P
G
Y
S
I
K
V
F
D
F
E
R
Cat
Felis silvestris
Mouse
Mus musculus
O35182
495
53696
G434
V
V
R
K
V
P
P
G
Y
S
I
K
V
F
D
Rat
Rattus norvegicus
O88406
426
46439
Y371
F
S
I
K
A
F
D
Y
E
K
A
Y
S
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516238
280
31765
D225
S
I
K
V
F
D
F
D
K
S
C
L
L
Q
H
Chicken
Gallus gallus
Q9W734
431
47806
I370
K
V
M
P
G
Y
S
I
K
V
F
D
Y
E
K
Frog
Xenopus laevis
NP_001091249
352
38824
Y297
Y
S
L
K
V
F
D
Y
K
K
S
C
V
L
R
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
F386
P
G
C
N
L
K
I
F
N
N
Q
E
F
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
E391
Q
S
V
N
N
G
F
E
A
V
Y
E
L
T
K
Honey Bee
Apis mellifera
XP_396816
251
28007
Y196
T
K
I
L
Q
L
P
Y
G
N
G
T
T
R
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
S316
K
I
Y
D
H
A
K
S
K
L
L
E
L
M
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
90.7
94.9
N.A.
93.3
42.5
N.A.
44.3
67.5
51
23.7
N.A.
22.5
29.2
N.A.
38.9
Protein Similarity:
100
99.4
90.9
95.7
N.A.
94.3
54.2
N.A.
49.7
73.1
58
39.9
N.A.
38.9
34.4
N.A.
50.2
P-Site Identity:
100
100
100
6.6
N.A.
6.6
6.6
N.A.
0
6.6
6.6
0
N.A.
13.3
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
13.3
N.A.
20
26.6
N.A.
6.6
26.6
13.3
0
N.A.
33.3
13.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
0
8
0
8
0
0
8
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
8
8
0
0
0
% C
% Asp:
0
0
0
8
0
8
16
8
0
0
0
16
24
0
8
% D
% Glu:
0
0
0
0
0
0
0
8
8
0
0
24
0
16
24
% E
% Phe:
8
0
0
0
8
16
16
8
0
0
16
24
16
31
0
% F
% Gly:
0
8
0
0
16
31
0
8
8
0
8
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
16
% H
% Ile:
0
16
16
0
0
0
8
16
24
0
8
0
0
0
0
% I
% Lys:
24
31
8
24
0
8
8
0
39
39
0
8
0
0
16
% K
% Leu:
0
0
8
8
8
8
0
0
0
8
8
8
24
16
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
16
8
0
0
0
8
16
0
0
0
0
0
% N
% Pro:
8
0
8
39
24
8
16
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
8
0
0
0
0
0
8
0
0
8
8
% Q
% Arg:
24
0
8
0
0
0
0
0
0
0
0
0
0
8
16
% R
% Ser:
8
24
0
0
0
0
16
31
0
16
8
0
8
0
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
8
8
8
8
% T
% Val:
8
24
31
8
16
0
0
0
0
24
24
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
16
24
24
8
0
8
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _